Location: US-45 and 2nd St, Brookport Welcome to Illinois and Brookport! Location: US-45 and 2nd St, Brookport Brookport is located right on the Illinois side of the Ohio River. Location: Ohio Ave and 3rd St, Brookport Reassurance shield as we enter Illinois. Location: US-45 and Unionville Rd, Massac Cty As we head out of Brookport, … Continue reading U.S. Route 45, KY State Line to IL-145